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In the chemical and pharmaceutical sciences, both phases usually are solvents.[2] Most commonly, one of the solvents is water while the second is hydrophobic such as 1 octanol.[3] Hence the partition coefficient measures how hydrophilic (“water loving”) or hydrophobic (“water fearing”) a chemical substance is. Partition coefficients are useful in estimating the distribution of drugs within the body. Hydrophobic drugs with high octanol/water partition coefficients are mainly distributed to hydrophobic areas such as lipid bilayers of cells.

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